Effect on Ocular urvival of Adding Early Intenive Focal Treatment to a Two-Drug Chemotherapy Regimen in Patient With Retinoblatoma

Purpoe To evaluate vincritine and carboplatin with intenive focal treatment in the management of intraocular retinoblatoma. Deign Noncomparative, retropective interventional cae erie. Method etting: Intitutional. Patient population: ixteen patient (11 bilateral, 5 unilateral) with intraocular retinoblatoma. Interventional procedure: Patient were treated with eight coure of vincritine and carboplatin. Intenive focal treatment were adminitered after two coure of chemotherapy. Main outcome meaure: Avoidance of external beam radiotherapy (EBRT) and eye urvival. Reult Twenty eye (74.1%) were claified a Reee-Ellworth Group V. All eye reponded to chemotherapy. With a median follow-up of 23 month (range 10 to 33 month) and a median of 5.5 focal treatment per eye (range 0 to 19 treatment), ocular urvival wa 81%. Eight eye (30%) in five patient received EBRT. Concluion Vincritine and carboplatin combined with intenive focal treatment i an effective regimen for patient with intraocular retinoblatoma. Thi treatment regimen ha outcome comparable to thoe of more toxic regimen and merit further evaluation.