A Common Dieae Haplotype for the Q368TOP Mutation of the Myocilin Gene in Autralian and Canadian Glaucoma Familie

Purpoe To acertain whether there i a common dieae haplotype for the Q368TOP mutation of the myocilin gene in Autralian and Canadian familie with primary open-angle glaucoma (POAG). Deign Family pedigree tudy. Method A dieae haplotype for the Q368TOP mutation of the myocilin gene ha previouly been identified in 15 Tamanian familie with POAG. The four microatellite marker that contitute thi 0.14-megabae (Mb) dieae haplotype were genotyped in individual from a large French Canadian family with POAG (family CT) and two unrelated French Canadian individual with ocular hypertenion. Reult The Tamanian Q368TOP dieae haplotype wa identified in affected individual from family CT, and the ame allele were hared at the four microatellite marker in the two unrelated French Canadian individual. Concluion The ame dieae haplotype for the Q368TOP mutation of the myocilin gene wa found in both the Tamanian and French Canadian population, upporting the view that thi mutation aroe from a common Caucaian founder.