Ultrahigh Reolution Optical Coherence Tomography In Macular Dytrophy

Purpoe To viualize and invetigate intraretinal change in macular dytrophie with ultrahigh reolution optical coherence tomography (UHR OCT). Deign Propective obervational cae erie. Method etting: Department of Ophthalmology and Center for Biomedical Engineering and Phyic, Chritian Doppler Laboratory, Medical Univerity of Vienna, Vienna, Autria. patient: Thirteen patient (23 eye) with adult-onet foveomacular vitelliform dytrophy (AOFVD) and 14 patient (27 eye) with targardt’ dieae (D) or fundu flavimaculatu (FF). Obervation Imaging uing a compact, new generation UHR OCT ytem, achieving coniderably improved viualization of intraretinal layer, epecially the photoreceptor layer. main outcome meaure: UHR OCT tomogram viualizing intraretinal difference in morphology of AOFVD and D/FF a location and extenion of depoit and lo of photoreceptor. Central foveal thickne defined a ditance between internal limiting membrane and photoreceptor/retinal pigment epithelium interface. Reult Patient with AOFVD had a motly intact photoreceptor layer, a central foveal thickne of 142 ± 23 μm a well a ubretinal depoit. Patient with D generally had a diffue degenerative change with a viible reduction in thickne of all intraretinal layer, reulting in a correponding reduction of central foveal thickne (94 ± 38 μm) and central lo of photoreceptor (PR). Comparative central foveal thickne of patient with AOFVD and D/FF wa ignificantly different (P < .001). Patient with FF had pigment epithelial depoit and paracentral focal photoreceptor lo. Concluion UHR OCT i a clinically feaible tool for examining intraretinal change, in particular photoreceptor atrophy in macular dytrophie and, therefore, ha the potential to be an adequate imaging ytem for monitoring the coure of dieae.