Reult of Penetrating Keratoplaty for Viual Rehabilitation After Acanthamoeba Keratiti

Purpoe To ae the reult of penetrating keratoplaty in quiet eye after reolution of Acanthamoeba keratiti. Deign A retropective interventional cae erie. Method Penetrating keratoplaty wa undertaken in 13 eye of 13 patient with an average age of 29 ± 13 year and a hitory of Acanthamoeba keratiti that wa diagnoed by culture and/or confocal microcopy between January 1995 and eptember 2004. All eye were oberved for at leat 3 month (average, 5 month) after the dicontinuation of antiamebic therapy that had been adminitered for at leat 4.5 month. In vivo confocal microcopy wa ued to enure that no reidual amoeba were preent before the operation. Two keratoplatie were combined with a valve inertion; five keratoplatie were combined with cataract extraction, and one keratoplaty wa preceded by a ciliary laer ablation. Reult Potoperative bet-corrected viual acuity ranged from 20/40 to 20/15, with the exception of one eye with advanced glaucoma that did not improve from a preoperative viion of light perception. No eye experienced rejection or amoebic recurrence, and 12 graft remained clear throughout the follow-up period (8 month to 9 year; median, 23 month). One graft failed at 4 month becaue of uncontrolled glaucoma. The eye wa regrafted, and the graft remained clear during the 28 month of follow-up evaluation. Two eye with preoperatively diagnoed glaucoma needed ubequent urgery to control their intraocular preure. Concluion Penetrating keratoplaty for viual retoration after Acanthamoeba keratiti appear to have an excellent long-term prognoi, provided amoebic infection ha reolved and concurrent glaucoma i controlled.