Intraoperative Enoxaparin Minimize Inflammatory Reaction After Pediatric Cataract urgery Original Reearch Article

Purpoe To evaluate the effect of intraocular infuion of enoxaparin, a low-molecular-weight heparin, on potoperative inflammatory repone in pediatric cataract urgery. Deign Propective, comparative, conecutive interventional cae erie. Method eventeen conecutive eye (11 patient) underwent pediatric cataract urgery in two tertiary medical center. During the procedure, balanced alt olution with enoxaparin (40 mg in 500 ml) wa infued into the anterior chamber. Eleven conecutive eye (eight patient) received balanced alt olution without enoxaparin in the infuion bottle. The inflammatory repone in the anterior chamber wa compared between the two group by emiquantification with lit-lamp biomicrocopy. Potoperative inflammatory complication, including fibrin formation, intraocular len precipitate, anterior and poterior ynechiae, cyclitic and pupillary membrane formation, and anterior ubluxation of the intraocular len, were alo compared. The follow-up period after urgery wa between 3 and 36 month (average 12.3 month). Reult The number of cell and the degree of flare were minimal in the group with enoxaparin in the infuion bottle (P < .001). The total number of potoperative inflammation-related complication wa alo lower in the enoxaparin-treated group (P = .007). All cornea remained clear, and the endothelial cell count, which wa performed in two patient, did not how ubtantial decreae in their denity or change in hape and ize. No other enoxaparin-related complication were oberved. Concluion Infuion of enoxaparin during pediatric cataract urgery may minimize the potoperative inflammatory repone and decreae the number of potoperative inflammatory related complication. Enoxaparin hould alo be evaluated for cataract urgery in other condition where potoperative inflammation may be exacerbated.