Topical Ibopamine in the Treatment of Chronic Ocular Hypotony Attributable to Vitreoretinal urgery, Uveiti, or Penetrating Trauma

Purpoe To tudy whether topical ibopamine effectively increae the intraocular preure in patient with ocular hypotony after vitreoretinal urgery, uveiti, or penetrating trauma. Deign A propective randomized, double-blind, placebo controlled, croover tudy. Method In ten patient with ocular hypotony, an ibopamine 2% olution or placebo eyedrop wa adminitered at 8 am and frequent applanation tonometry wa performed during 10 hour on 2 day, 2 week apart. Reult The mean IOP integral after adminitration of ibopamine wa 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minute [P = .010]) compared with placebo. Concluion The reult of the tudy how that an ibopamine 2% eyedrop twice a day may increae the IOP for a period of over 8 hour in patient with hypotony.