Central Corneal Thickne and Corneal Hyterei Aociated With Glaucoma Damage Original Reearch Article

Purpoe We ought to meaure the impact of central corneal thickne (CCT), a poible rik factor for glaucoma damage, and corneal hyterei, a propoed meaure of corneal reitance to deformation, on variou indicator of glaucoma damage. Deign Obervational tudy. Method Adult patient of the Wilmer Glaucoma ervice underwent meaurement of hyterei on the Reichert Ocular Repone Analyzer and meaurement of CCT by ultraonic pachymetry. Two glaucoma pecialit (H.A.Q., N.G.C.) reviewed the chart to determine highet known intraocular preure (IOP), target IOP, diagnoi, year with glaucoma, cup-to-dik ratio (CDR), mean defect (MD), pattern tandard deviation (PD), glaucoma hemifield tet (GHT), and preence or abence of viual field progreion. Reult Among 230 ubject, the mean age wa 65 ± 14 year, 127 (55%) were female, 161 (70%) were white, and 194 (85%) had a diagnoi of primary open-angle glaucoma (POAG) or upected POAG. In multivariate generalized etimating equation model, lower corneal hyterei value (P = .03), but not CCT, wa aociated with viual field progreion. When axial length wa included in the model, hyterei wa not a ignificant rik factor (P = .09). A thinner CCT (P = .02), but not hyterei, wa aociated with a higher CDR at the mot recent examination. Neither CCT nor hyterei wa aociated with MD, PD, or GHT “outide normal limit.” Concluion Thinner CCT wa aociated with the tate of glaucoma damage a indicated by CDR. Axial length and corneal hyterei were aociated with progreive field worening.