LXII Edward Jackon Lecture: Open Angle Glaucoma After Vitrectomy

Purpoe To preent data and an hypothei for the late development of open angle glaucoma (OAG) after vitrectomy. Deign A retropective obervational cae erie. Method The record of 453 eye that had undergone vitrectomy were reviewed for potoperative OAG. Eye with confounding factor were excluded. ixty-eight eye of 65 patient that underwent routine vitrectomy were followed for a mean of 56.9 month (range, even to 192 month). For the main outcome meaure, patient were claified into three group: patient with upected glaucoma, patient in whom glaucoma developed after the operation, and patient with pre-exiting glaucoma. Reult In glaucoma upect, the mean intraocular preure wa ignificantly higher in the operated eye compared with the fellow eye (P = .0001). In eye with new onet glaucoma, 23 of 34 eye (67.6%) had it in the vitrectomized eye only. In phakic eye, the time interval between vitrectomy and the development of glaucoma (mean, 45.95 month) wa ignificantly longer than eye that were nonphakic at the time of vitrectomy (mean, 18.39 month; P = .0115). When the interval between cataract urgery in phakic eye to the development of glaucoma wa compared with the interval from vitrectomy to glaucoma diagnoi in the nonphakic group, the difference wa not tatitically ignificant. In eye with glaucoma before the operation, the mean number of antiglaucoma medication that were required to control the intraocular preure wa ignificantly higher in the vitrectomized eye, compared with the fellow eye (2.9 medication ± 1.2 v 2.0 medication ± 1.4; P = .0215; n = 14). Concluion There i an increaed rik of OAG after vitrectomy. The preence of the len may be protective. In etablihed OAG before the operation, the number of antiglaucoma medication may increae after urgery. Oxidative tre i hypotheized to have a role in the pathogenei.