ucceful Tear Lipid Layer Treatment for Refractory Dry Eye in Office Worker by Low-Doe Lipid Application on the Full-Length Eyelid Margin Original Reearch Article

Purpoe To tet tear lipid layer treatment by low-doe lipid application on the full-length eyelid margin for the treatment of office worker with dry eye refractory to conventional treatment. Deign Propective interventional cae erie. Method Thirty eye of 30 office worker with dry eye with dark tear interference image, which did not repond to conventional treatment, were included. To upply lipid uing a commercially available nonpreerved topical medication having both polar and nonpolar lipid bae, ofloxacin eye ointment (anten Pharmaceutical, Oaka, Japan) wa elected. Low-doe ofloxacin ointment application on the full-length eyelid margin wa carried out three time a day for two week. The ymptom of ocular dryne uing a viual analog cale, tear interferometry to ae lipid layer thickne (LLT), corneal fluorecein taining, tear-film breakup time (BUT), and meibum expreibility grading were compared. Reult After the treatment, the ymptom core of ocular dryne decreaed from 91.4 ± 11.9 to 33.6 ± 21.0 (P < .0001), LLT increaed from 39 ± 4 nm to 161 ± 91 nm (P < .0001), BUT wa prolonged from 2.6 ± 1.6 econd to 4.8 ± 2.1 econd (P = .01), and meibum expreibility grading decreaed from 2.8 ± 1.3 to 1.6 ± 1.3 (P = .0005). Concluion For office worker with refractory dry eye, tear lipid layer treatment by low-doe ointment applied on the full-length eyelid margin wa hown to be an effective approach. The applied lipid formed a uniform lipid layer, which contributed to tear tability, leading to the improvement of the ymptom.