Rik Factor for Five-Year Incident Age-related Macular Degeneration: The Reykjavik Eye tudy Original Reearch Article

Purpoe To etablih rik factor for five-year incidence of age-related macular degeneration (AMD). Deign Population-baed, propective cohort tudy, and rik analyi. Method A random ample from the Reykjavik Population Cenu for individual 50 year and older wa elected. We took fundu tereo color photograph and ued tandard grading ytem to tudy the five-year incidence of druen, pigmentary abnormalitie, and AMD and to examine poible rik factor. A quetionnaire including information on dieae, medication, diet, and lifetyle from the Reykjavik Eye tudy databae provided additional information. Reult Current alcohol conumption decreaed the rik for druen. Being married rather than divorced or widowed decreaed the rik for oft druen; being ingle decreaed the rik of hypopigmentation a compared with being divorced or married. Both conuming dietary fiber–rich vegetable and meat and meat product once a week or le frequently wa a rik factor for developing oft druen and decreaed the rik of pigmentary abnormalitie. Thoe who had moked 20 pack-year or more a compared with nonmoker had decreaed urvival rate over the five year (odd ratio (OR) 0.46, 95% confidence interval (CI) 0.27 to 0.80; P = .006). Concluion Rik factor for druen appear to differ from rik factor for pigmentary abnormalitie. The effect of moking on developing AMD i partly maked by elective mortality.