Meaurement of the Actual Doe of Triamcinolone Acetonide Delivered by Common Technique of Intravitreal Injection Original Reearch Article

Meaurement of the Actual Doe of Triamcinolone Acetonide Delivered by Common Technique of Intravitreal Injection Original Reearch Article 597-600.e1 Michael D. Ober, Gaetano R. Barile, amir R. Tari, Gian M. Toi, William M. chiff, tanley Chang Cloe Cloe preview | Purchae PDF (420 K) | Related article | Related reference work article AbtractAbtract | Figure/TableFigure/Table | ReferenceReference Purpoe To meaure the actual doe of triamcinolone acetonide (TA) delivered during intravitreal injection performed by everal common technique. Deign Experimental tudy. Method A 0.1-ml, 40-mg vial of TA (Kenalog-40; Britol-Myer-quibb, Peapack, New Jerey, UA) wa prepared according to one of four protocol and the ma determined after drying overnight on waxed paper. In group 1, a 0.1-ml aliquot of TA wa dipened with a 30-gauge needle after haking the vial 10 or 30 time. Group 2 ued a 27-gauge needle. In group 3, the upernatant wa removed from the crytal. Group 4 paed the upenion through a 0.2-μm micropore filter and rined the crytal with aline. Reult There wa no tatitically ignificant difference between 30- or 27-gauge needle (P = 0.83, t tet) or between haking the vial 10 or 30 time before withdrawing the drug (P = 0.99). A tatitically ignificant difference (t tet, P = 0.001) wa found between TA delivered from the initial 60% of each yringe (mean ± D, 2.7 ± 1.0 mg) to that drawn from the lat 40% of each yringe (7.8 ± 3.6 mg). Group 3 had a mean weight of 32.1 ± 7.0 mg and group 4, 10.6 ± 2.1 mg. Concluion Effort to achieve a 4.0-mg doe of TA, regardle of method ued, are variable and inconitent. Injecting through a mall-gauge needle appear to concentrate the remaining upenion. Technique to concentrate TA or remove aqueou preervative by filtering effectively increae the concentration, but thee reult are variable. Article Outline Method Reult Dicuion Reference Vitae