In vitro Activity of Fluoroquinolone, Vancomycin, and Gentamicin Againt Methicillin-Reitant taphylococcu aureu Ocular Iolate Original Reearch Article

Purpoe To determine the antibacterial activity of fluoroquinolone, vancomycin, and gentamicin againt methicillin-reitant taphylococcu aureu (MRA) ocular urface iolate. Deign Retropective review. Method MRA iolate were obtained from 21 patient. The MIC50 (mean inhibitory concentration)(μg/ml) value of 31 MRA ocular urface iolate were determined for gatifloxacin, moxifloxacin, ciprofloxacin, ofloxacin, vancomycin, and gentamicin uing the Etet (AB Biodik, olna, weden) or the VITEK ytem (bioMérieux, Inc, Durham, North Carolina, UA). uceptibility data were interpreted baed on criteria pecified by the Clinical and Laboratory tandard Intitute (CLI). main outcome meaure: MIC50 value in μg/ml and interpretation of uceptibility or reitance. Reult In vitro reitance rate and median MIC50 in μg/ml for the MRA iolate were: gatifloxacin (71%, 8.0), moxifloxacin (68%, 8.0), ciprofloxacin (94%, 8.0), ofloxacin (94%, 8.0), vancomycin (0%, 1.0), and gentamicin (3%, 0.5). Concluion MRA ocular iolate exhibited a relatively high rate of in vitro reitance to all fluoroquinolone teted, including the fourth generation. In contrat, MRA iolate were found to be highly enitive to vancomycin and gentamicin.