Progreive Viual Lo in ubfoveal Exudation in Age-related Macular Degeneration: A Meta-analyi Uing Lineweaver-Burke Plot Original Reearch Article

Purpoe To analyze the randomized clinical trial in exudative age-related macular degeneration (AMD) to reveal apparent difference in the behavior of untreated control eye among thee trial. Herein we tet the hypothei that the behavior of untreated control eye i actually the ame in all tudie, with apparent difference ariing from difference in the time of entry of eye into clinical trial. Deign Retropective meta-analyi of prior clinical trial. Method Control eye data from ix AMD tudie (Macular Photocoagulation tudy, ubfoveal urgery Trial, Photodynamic Therapy [TAP] With Viudyne, pegaptanib trial for neovacular AMD, anecortave acetate trial, and 360 degree Macular Tranlocation tudy) were plotted on a double reciprocal plot of 1/(Letter Lot) v 1/(Month After Enrollment). To account for difference in time of entry into clinical trial, we introduced a horizontal tranlation factor to hift each data ubet horizontally to maximize r2 for the cumulative trend line. Reult Cumulative data for untreated control eye fit a traight line on a double reciprocal plot (r2 = .9521); an untreated eye would eventually deteriorate to a final viion of 20/640. The lope of the line predict that patient would experience half of the maximum final viion within 10.88 month after exudation onet. Concluion The pattern of viion lo experienced in AMD eye with ubfoveal neovacularization i uniform acro a wide range of clinical trial, with apparent difference ariing from difference in the time of entry of patient into clinical trial.