Central Toxic Keratopathy: Decription of a yndrome in Laer Refractive urgery Original Reearch Article

Purpoe To decribe the clinical pectrum of a yndrome in laer refractive urgery, which we call central toxic keratopathy, and to preent cae that illutrate the range of thi yndrome. Deign Retropective obervational cae erie. Method Eye with noninflammatory central corneal opacification in the immediate potoperative period after photorefractive keratectomy (PRK) or laer in itu keratomileui (LAIK) were identified, and the chart abtracted. Reult Twenty-three eye of 14 patient were identified who developed central corneal opacification three to nine day after laer refractive urgery. Nineteen of thee eye had LAIK and four had PRK. All eye had central corneal opacification in the area of laer treatment that extended poteriorly from the interface into the tromal bed (in the cae of LAIK eye). The opacification perited a minimum of two month to a maximum of 18 month before clearing. Nine eye developed potoperative hyperopia of greater than 2 diopter. Pre- and potoperative bet-pectacle corrected acuity wa available on 19 eye; one of thee eye lot two line of corrected acuity, and two other eye lot one line. Eighteen of 19 LAIK eye had diffue lamellar keratiti preceding the onet of corneal opacification. Concluion Central toxic keratopathy i characterized by noninflammatory central corneal opacification with a ignificant hyperopic hift. The opacification gradually clear over a period of month, leaving the eye hyperopic. Enhancement i indicated to treat reidual hyperopia and remove reidual triae. Topical or oral corticoteroid treatment i not indicated. The caue of central toxic keratopathy i unknown.