Itchy-Dry Eye Aociated with Polycytic Ovary yndrome Original Reearch Article

Purpoe The author aimed to define the ocular ymptomatology of women with polycytic ovarie and hyperandrogenim. Deign Propective, obervational cae erie. Method Of the 62 conecutive patient with an ultraonographic diagnoi of polycytic ovary (PCO), 16 were identified a having clinical and biochemical ign of hyperandrogenim. All women with a hitory of ocular ymptom (20/62 total patient [32.3%], 15/16 polycytic ovary yndrome (PCO) patient [93.7%], and 5/46 PCO patient [10.8%]) underwent a complete eye examination with conjunctival impreion cytologic ampling. Clinical meaurement of tear function (tear film break-up time [BUT], chirmer I tet) were completed along with analyi of conjunctival goblet cell number, conjunctival immunotaining, and revere-trancriptae polymerae chain reaction for the mucin MUC1 and MUC5AC. Clinical, hitologic, and biochemical data of patient with PCO were compared tatitically with that of patient with PCO and with eight age- and gender-matched healthy control. Eight of the mot everely affected patient received ytemic antiandrogen therapy and underwent further ocular evaluation four month after ytemic therapy. Reult Women with PCO had greater conjunctival hyperemia (P < .001), dryne (P < .001), itching (P < .001), mucou dicharge (P < .001), and contact len intolerance (P < .001) than patient with PCO. Patient with PCO had a ignificant reduction of the tear film BUT accompanied by a ignificant increae in goblet cell number and conjunctival MUC5AC meenger ribonucleic acid expreion compared with both PCO patient and healthy ubject. Concluion Evaluation of the ocular urface hould be conidered in patient with PCO or PCO. Women with PCO were more likely to have itchy-dry eye, decreaed tear film BUT, and increaed goblet cell denity.