Differential Aqueou and Vitreou Concentration of Moxifloxacin and Ofloxacin After Topical Adminitration One Hour before Vitrectomy

Purpoe To invetigate the penetration of ofloxacin and moxifloxacin into the aqueou and vitreou after topical adminitration one hour before vitrectomy urgery. Deign Propective, randomized, double-blind cae erie tudy. Method Twenty-even patient undergoing vitrectomy were randomized to receive either topical ofloxacin 0.3% or moxifloxacin 0.5% every 10 minute for one hour before urgery. Aqueou and vitreou ample were obtained and analyzed uing high-performance liquidation chromatography. Reult The moxifloxacin aqueou (1.576 ± 0.745 μg/ml) and vitreou (0.225 ± 0.013 μg/ml) level were ignificantly higher than the ofloxacin aqueou (0.816 ± 0.504 μg/ml) (P = .0009) and vitreou (0.225 ± 0.013 μg/ml) [P = .0054] level, repectively. The mean moxifloxacin aqueou and vitreou level exceeded the minimum inhibitory concentration for 90% of iolate (MIC90) for a wide variety of bacteria implicated in endophthalmiti. In contrat, the aqueou level of ofloxacin exceeded the MIC90 of only a few organim. Concluion Moxifloxacin applied every 10 minute during the hour before vitrectomy penetrated the eye ignificantly better than ofloxacin.