Antibiotic uceptibility of Bacterial Iolate from Bacterial Keratiti Cae in a Univerity Hopital in Taiwan Original Reearch Article

Purpoe To analyze in vitro antibiotic uceptibility of bacterial iolate from patient with bacterial keratiti at the National Taiwan Univerity Hopital over the pat 12 year. Deign Retropective cro-ectional tudy. Method Medical record were reviewed for patient with culture-proven bacterial keratiti at the National Taiwan Univerity Hopital from January 1994 to December 2005. Microbial iolation and in vitro antibiotic uceptibility were analyzed. Reult A total of 272 pathogen were iolated from 254 eye. Peudomona pecie were the mot commonly iolated organim (46.7%), followed by taphylococcu pecie (11%), Propionibacterium pecie (8.1%), treptococcu pecie (7.6%), and nontuberculou Mycobacteria (6.6%). There wa no ignificant change in antibiotic uceptibility in the train of taphylococcu, treptococcu, Peudomona, or nontuberculou Mycobacteria during the tudy period. From 1994 to 2005, 81.8% of the gram-negative organim were uceptible to the combination of cefazolin and gentamicin, wherea 95.8% were uceptible to ciprofloxacin (P < .001). For all bacterial iolate, 83.7% and 89.7% were uceptible to the combination of cefazolin and gentamicin and the combination of cefazolin and ciprofloxacin, repectively (P < .001). Concluion There wa no increae in drug reitance in train of Peudomona, taphylococcu, treptococcu, or nontuberculou Mycobacteria from 1994 to 2005. Ciprofloxacin i a more efficaciou choice than the combination of cefazolin and gentamicin for gram-negative bacterial keratiti in Taiwan. The combination of cefazolin and ciprofloxacin i an effective empirical therapeutic regimen for bacterial keratiti.