Central Retinal Vein Occluion Cae-Control tudy

Purpoe To invetigate rik factor for central retinal vein occluion (CRVO). Deign Retropective cae-control tudy. Method Conecutive patient with CRVO examined from July 1, 2005 through July 31, 2006 were compared with an hitorical gender- and age-matched control group of patient with ocular problem other than vacular occluive dieae from the ame referral practice. Rik factor for CRVO were evaluated. Reult The 144 patient in the CRVO group, 87 male and 57 female, had a mean age of 69.6 year (±13.6 year). CRVO wa aociated with hypertenion (P < .001), diabete mellitu (P = .047), glaucoma (P < .001), atrial fibrillation (P = .036), angiotenin-converting enzyme inhibitor ue (P = .022), apirin ue (P < .001), and warfarin ue (P = .011) by univariate analye. Potmenopaual etrogen ue wa more common among women in the control group (P = .029). Multivariate logitic regreion found the independent predictor for CRVO to be: glaucoma (adjuted odd ratio [OR], 4.75; P < .001), apirin ue (adjuted OR, 2.66; P = .001), and warfarin ue (adjuted OR, 3.34; P = .005). Concluion We found many of the ame rik factor previouly identified for CRVO by other tudie, but we identified both apirin and warfarin ue to be independent rik factor for CRVO. Although thee finding ugget the vaculopathic and prothrombotic rik in ome patient may not be addreed adequately by antithrombotic therapy, they alo ugget that the pathogenei of CRVO may be more complicated than jut the development of a primary thrombu within the vein.