Concomitant Choroidal Inflammation during Anterior egment Recurrence in Vogt-Koyanagi-Harada Dieae Original Reearch Article

Purpoe To determine whether clinically iolated anterior egment recurrence i aociated with concomitant ubclinical choroidal inflammation in Vogt-Koyanagi-Harada (VKH) dieae. Deign Interventional, retropective cae erie. Method Nine patient with recurrent VKH dieae who atified the following criteria: 1) preence of anterior chamber (AC) inflammation of at leat 1+ cell after a period of quiecence of three month or more, 2) no poterior egment involvement, and 3) indocyanine green angiography (ICGA) performed during the time of anterior egment recurrence at the ingapore National Eye Centre. ICGA wa performed. Therapy wa adminitered baed on clinical feature. The main outcome meaure were the ICGA feature. Reult Twelve eye of nine patient were included in the tudy. All eye had mild AC inflammation of 1 to 2+ cell, except for one eye that had 3+ cell. ICGA howed early large veel hyperfluorecence, becoming fuzzy in character in the intermediate phae in 11 of 12 eye with AC inflammation. In four eye, few hypofluorecent dot were een in the intermediate phae that remained hypofluorecent in the late phae. Late diffue hyperfluorecence wa oberved in five eye. All patient received high-doe oral predniolone and topical predniolone acetate. Four patient required additional teroid-paring immunouppreant. All patient attained clinical quiecence within two week to two month. Repeat ICGA howed abence of active leakage, ignificant decreae in choroidal vacular leakage, or no change in the number and denity of hypofluorecent pot. Concluion Iolated anterior egment recurrence in VKH dieae may occur concomitantly with ubclinical choroidal inflammation and require ytemic therapy.