Intraocular Preure Elevation after Injection of Triamcinolone Acetonide: A Multicenter Retropective Cae-Control tudy Original Reearch Article

Purpoe To determine the rik factor for intraocular preure (IOP) elevation after the injection of triamcinolone acetonide (TA). Deign Retropective interventional cae-control tudy. Method etting: Multicenter. patient population: Four hundred and twenty-even patient. obervation procedure: Intraocular preure level after TA treatment by the ub-Tenon capule injection (TI; 12 mg, 20 mg, or 40 mg), intravitreal injection (IVI; 4 mg or 8 mg), or the combination of TI (20 mg) and IVI (4 mg), and IOP level after two TA treatment. main outcome meaure: Rik factor for IOP level of 24 mm Hg or higher. Reult Younger age (hazard ratio [HR], 0.96/year; P < .0001), IVI (HR, 1.89/year; P < .0001), and higher baeline IOP (HR, 1.15/mm Hg; P = .003) were identified a rik factor. Doe dependency wa hown in TI-treated eye (HR, 1.07/mg; P = .0006), a well a after IVI (HR, 1.64/mg; P = .013). The combination of TI and IVI wa a ignificant rik factor (HR, 2.27; P = .003) compared with TI alone. In eye receiving two TA treatment, IVI (HR, 2.60; P = .010), higher IOP elevation after the firt injection (HR, 1.18/mm Hg; P = .011), and increaed doage of TI (HR, 1.07/mm Hg; P = .033) were rik factor. Concluion Younger age, higher baeline IOP, IVI, and increaed TA doage were aociated with TA-induced IOP elevation. IOP elevation after repeated TA injection wa frequently aociated with eye treated with IVI, high IOP elevation after the firt injection, and high doe of TI.