Aociation of LOC387715 A69 With Vitreou Hemorrhage in Polypoidal Choroidal Vaculopathy Original Reearch Article

Purpoe To invetigate whether the LOC387715 polymorphim i aociated with polypoidal choroidal vaculopathy (PCV) and with vitreou hemorrhage (VH), one of the mot evere clinical phenotype, in the Japanee population. Deign Cro-ectional cae-control aociation tudy. Method One hundred and nine Japanee patient with PCV, compoed of nine patient aociated with VH (VH group) and 100 patient without VH (non-VH group), and 85 control ubject were analyzed for the LOC387715 polymorphim (r = 10490924), uing denaturing high-performance chromatography. Reult There wa a ignificant difference in the T allele frequency between PCV patient and control ubject (P < .0001). In comparion with wild-type homozygoity (GG), homozygoity for the at-rik allele genotype (TT) increaed the likelihood for PCV 8.4-fold (3.6 to 19.5, 95% confidence interval [CI]) and heterozygoity for the at-rik allele genotype (TG) increaed the likelihood for PCV 4.0-fold (1.9 to 8.4, 95% CI). There wa a ignificant difference in the genotypic frequency at the LOC387715 ite between the VH and non-VH group (P = .0099, Chi-quare tet) with the TT genotype occurring in 88.9% in the VH group and 37.0% in the non-VH group. The frequency of the T allele in the VH group wa ignificantly greater than that in the non-VH group (0.944 v 0.610; P = .0039, Fiher exact tet). Concluion The LOC387715 polymorphim i aociated with PCV and clinical everity in the ubgroup of PCV in the Japanee population.