Photoreceptor Outer egment Abnormalitie a a Caue of Blind pot Enlargement in Acute Zonal Occult Outer Retinopathy–Complex Dieae Original Reearch Article

Purpoe To invetigate the correlation between viual field (VF) defect in dieae of the acute zonal occult outer retinopathy (AZOOR)-complex and their pectral-domain optical coherence tomographic (OCT) finding. Deign Obervational cae erie. Method Patient with AZOOR, multiple evanecent white dot yndrome (MEWD), and multifocal choroiditi and panuveiti (MCP) examined in a private practice retinal referral center had threhold VF teting and pectral-domain OCT examination performed uing a device capable of obtaining a block of 128 B-can in a 6 × 6-mm region centered on the optic nerve and macula. The area of defect in the boundary between the inner egment (I) and the outer egment (O) of the photoreceptor, termed the I/O boundary, were compared with the VF defect meaured. Reult There were 18 evaluable eye among one patient with MEWD, two with AZOOR, and even with MCP. In the 14 eye with blind pot enlargement, correponding I/O boundary defect were found in the four eye peripapillary region, while no I/O boundary defect were found in the five eye without blind pot enlargement. I/O boundary defect were een over chorioretinal car and area of neovacularization and no widepread defect were een elewhere in the fundu. The I/O boundary defect howed improvement, a did the blind pot enlargement, pontaneouly in the patient with MEWD and after treatment with immunouppreion in the patient with AZOOR. Concluion The pectral-domain OCT finding of I/O boundary defect, implicating photoreceptor O perturbation, appear to explain the blind pot enlargement in patient with AZOOR-complex dieae. Thee defect are not necearily permanent.