Longitudinal tudy of New Eye Leion in Children with Toxoplamoi Who Were Not Treated During the Firt Year of Life Original Reearch Article

Purpoe To determine the incidence of new chorioretinal leion in children with toxoplamoi diagnoed after, and therefore not treated during, their firt year. Deign Propective longitudinal cohort tudy. Method Thirty-eight children were evaluated in Chicago between 1981 and 2005 for new chorioretinal leion. Thirty-eight children and mother had erum IgG antibody to Toxoplama gondii. Reult Twenty-eight of 38 children had one of the following: diagnoi with erum antibody to T. gondii indicative of chronic infection at age 24 month, central nervou ytem calcification, hydrocephalu, illne compatible with congenital toxoplamoi perinatally but not diagnoed at that time. Twenty-five returned for follow-up during 1981 to 2005. Their mean (range) age at lat exam wa 10.9 ± 5.7 (range, 3.5 to 27.2) year and mean follow-up wa 5.7 ± 2.9 year. Eighteen (72%) children developed at leat one new leion. Thirteen (52%) had new central leion, 11 (44%) had new peripheral leion, and ix (24%) had both. Thirteen (52%) had new leion diagnoed at age ≥10 year. New leion were found at more than one viit in four (22%), and bilateral new leion developed in even (39%) of 18 children who developed new leion. Of 10 additional children with eye finding and erologic tet indicative of chronic infection, ix returned for follow-up, four (67%) developing new leion at ≥10 year of age. Concluion More than 70% developed new chorioretinal leion. New leion were commonly diagnoed after the firt decade of life.