Effect of Aging on Corneal Biomechanical Propertie and Their Impact on 24-hour Meaurement of Intraocular Preure Original Reearch Article

Purpoe To tudy the effect of aging on corneal biomechanical propertie and their impact on 24-hour meaurement of intraocular preure (IOP). Deign Experimental tudy. Method Fifteen older volunteer with healthy eye (age range, 50 to 80 year) were houed for one day in a leep laboratory with a 16-hour diurnal or wake period and an eight-hour nocturnal or leep period. Every two hour, itting corneal hyterei, corneal reitance factor, and IOP were meaured. Central corneal thickne (CCT) wa meaured uing an ultraound pachymeter. Data were compared with previou obervation in 15 healthy younger volunteer (age range, 20 to 25 year). Reult Variation in 24-hour corneal hyterei and corneal reitance factor were not ignificant in the older ubject, but there were time-dependent variation in CCT and IOP. The nocturnal CCT wa thicker than the diurnal CCT, but the IOP difference between the diurnal and nocturnal period wa not ignificant. Coine-fit of CCT and IOP howed ynchronized 24-hour rhythm. The phae timing of CCT rhythm appeared ignificantly earlier than the phae timing of IOP rhythm. Compared with younger ubject, older ubject had a lower mean 24-hour corneal hyterei and corneal reitance factor, but not a lower CCT. Phae timing of 24-hour rhythm of CCT and IOP were ignificantly delayed by aging. Concluion Aging may lower corneal hyterei and corneal reitance factor, but neither parameter how a ignificant 24-hour variation. Aging may not change CCT ignificantly, but can hift it 24-hour rhythm. The 24-hour IOP pattern in thi group of older ubject i not an artifact reulting from a variation in corneal hyterei, corneal reitance factor, or CCT.