Intravenou Thrombolyi With Low-doe Recombinant Tiue Plaminogen Activator in Central Retinal Artery Occluion Original Reearch Article

Purpoe To evaluate the beneficial effect of intravenou thrombolyi aiming at rapid retoration of blood flow during the early hour of a central retinal artery occluion (CRAO). Deign Interventional cae erie. Method In the preent tudy, we propectively evaluated the viual outcome after thrombolytic treatment with low-doe (50 mg) rt-PA (recombinant tiue plaminogen activator) and concomitant intravenou heparinization in patient with acute CRAO, bet-corrected viual acuity (BCVA) ≤ 20/100, and onet of ymptom within 12 hour prior to treatment. Reult Twenty-eight patient (28 eye) were included in thi tudy. Final viual acuity wa improved three or more line in nine eye (32%), table in 18 (64%), and wore in one eye. Time to treatment ≤ 6.5 hour wa aociated with a better gain of line of viion (P = .004). even of 17 eye (41%) that received thrombolytic treatment within the firt 6.5 hour achieved a final BCVA ≥ 20/50, compared to none in the ubgroup of patient with onet to treatment >6.5 hour (P = .023). We oberved no eriou advere event. Concluion Our finding indicate that thrombolytic treatment with intravenou low-doe rt-PA i of value for an improved viual recovery in patient with acute CRAO, if adminitered within the firt 6.5 hour after the onet of ymptom.