Title of article :
Increased number of high sensitive platelets in hypercholesterolemia, cardiovascular diseases, and after incubation with cholesterol Original Research Article
Author/Authors :
C. Opper، نويسنده , , C. Clement، نويسنده , , H. Schwarz، نويسنده , , J. Krappe، نويسنده , , A. Steinmetz ، نويسنده , , J. Schneider، نويسنده , , W. Wesemann، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
7
From page :
211
To page :
217
Abstract :
The number of low density platelets was found to be increased in patients with hypercholesterolemia, as compared with the number in controls. The percentage increase of the low density platelet subpopulation was even more pronounced in patients with hypercholesterolemia when compared with that in patients suffering from myocardial infarction or angina. In vitro studies with control platelets incubated with cholesterol rich liposomes showed also an increase in the subpopulation of low density platelets. After incubation of control platelets with cholesterol rich liposomes, a higher membrane anisotropy and a higher cholesterol to phospholipid (C/P) molar ratio of the plasma membrane were found. Furthermore, cholesterol-enriched platelets were more sensitive upon thrombin stimulation. The results suggest that a shift of platelet subpopulations to a higher number of low density platelets could be caused by either the level of plasma cholesterol or an in-vitro incubation with cholesterol rich liposomes.
Keywords :
phospholipids , liposomes , Hypercholesterolemia , cardiovascular diseases , Platelets , cholesterol
Journal title :
Atherosclerosis
Serial Year :
1995
Journal title :
Atherosclerosis
Record number :
627559
Link To Document :
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