Fibrinogen, angina and coronary heart disease in a Chinese population

Although fibrinogen is an established risk factor of coronary heart disease (CHD), whether fibrinogen is associated with CHD in Chinese is not clear. This population-based cross-sectional study aimed to analyse this relationship in Hong Kong Chinese. Fibrinogen was measured by the Clauss method in 1348 men and 1385 women aged 25–74 years. Severity of CHD was defined as most serious if the subjects had medically diagnosed CHD, as less serious if they had angina only, and as normal if they had neither. The prevalence of angina and CHD was respectively 2.4% and 2.2% in men and 3.2% and 2.7% in women. In men the age-adjusted mean fibrinogen concentration was 2.47 (95% confidence interval (CI) 2.43–2.51) g/l in the normal group, 2.65 (95% CI 2.45–2.85) g/l in the angina group, and 2.78 (95% CI 2.56–3.00) g/l in the CHD cases (P<0.01); in women it was respectively 2.61 (95% CI 2.59–2.63), 2.66 (95% CI 2.50–2.82), 2.90 (95% CI 2.72–3.08) g/l (P<0.01). The differences were significant after adjustment of other significant risk factors. We conclude that fibrinogen should be considered as a risk factor in Chinese.