Title of article :
T102C polymorphism of the serotonin (5-HT) 2A receptor gene in patients with non-fatal acute myocardial infarction
Author/Authors :
Shinichiro Yamada، نويسنده , , Hozuka Akita، نويسنده , , Kenji Kanazawa، نويسنده , , Tatsuro Ishida، نويسنده , , Ken-ichi Hirata، نويسنده , , Keiichi Ito، نويسنده , , Seinosuke Kawashima، نويسنده , , Mitsuhiro Yokoyama، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
Serotonin (5-HT), released from activated platelets, has been implicated in the pathogenesis of acute myocardial infarction (AMI). 5-HT induces platelet aggregation and vascular contraction through 5-HT2A receptor activation at sites of coronary atherosclerosis, leading to thrombus formation. Recently, a 5-HT2A receptor gene T102C polymorphism has been reported to be associated with clinical response to 5-HT2A receptor antagonist in patients with schizophrenia, suggesting this polymorphism of the gene affects the 5-HT2A receptor function. To investigate the relationship between the T102C polymorphism and AMI, we conducted a case-control study of 255 non-fatal AMI patients and 255 control subjects. Among the patients, the prevalence of TT genotype was significantly higher than in controls (32.5 vs. 24.3%; P<0.05). In male patients (n=216), the prevalence was much higher than in control subjects (33.8 vs. 24.1%, P<0.03). In multiple logistic regression models, odds ratio of TT genotype was 1.45 (95% CI 0.96–2.20) in all and 1.61 (95% CI 1.03–2.53) (P<0.05) in males. The association of T102C polymorphism of the 5-HT2A receptor gene with non-fatal AMI was statistically significant and independent of other risk factors in males. The TT genotype of the 5-HT2A receptor gene may enhance susceptibility to AMI. Our observations suggest that the T102C polymorphism of the 5-HT2A receptor gene can serve as a new genetic marker for AMI.
Keywords :
myocardial infarction , platelet , genetics , risk factors
Journal title :
Atherosclerosis
Journal title :
Atherosclerosis