Author/Authors :
Tadashi Suehiro، نويسنده , , Toshihiro Nakamura، نويسنده , , Mari Inoue، نويسنده , , Tomoko Shiinoki، نويسنده , , Yukio Ikeda، نويسنده , , Yoshitaka Kumon، نويسنده , , Masanori Shindo، نويسنده , , Hideo Tanaka، نويسنده , , Kozo Hashimoto، نويسنده ,
Abstract :
Human serum paraoxonase (PON1) is an esterase that has been shown to decrease the susceptibility of lipoproteins to lipid peroxidation. We found a polymorphism of cytosine/thymidine (−108C/T, the number is from the ATG codon) in the upstream region of the PON1 gene. The luciferase activity was lower in the −108T allele than in the −108C allele. The serum PON1 concentrations in 132 normal subjects were as follows: −108CC>−108CT and>−108TT genotypes. The polymorphism upstream from the PON1 gene is associated with transcription of the PON1 gene and the serum PON1 concentration.
Keywords :
Paraoxonase , genetic polymorphism , coronary heart disease , Lipid peroxidation
