Title of article :
The calcium inhibitor SR33805 reduces intimal formation following injury of the porcine carotid artery
Author/Authors :
Patricia Hainaud، نويسنده , , Michel Bonneau، نويسنده , , Georges Pignaud، نويسنده , , Claire Bal dit Sollier، نويسنده , , Patrick André، نويسنده , , Peter Hadjiisky، نويسنده , , Jean Paul Fieffé، نويسنده , , Jacques P. Caen، نويسنده , , Jean Marc Herbert، نويسنده , , Frédérique Dol، نويسنده , , Ludovic O. Drouet، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
8
From page :
301
To page :
308
Abstract :
We studied the effect of SR33805, a calcium channel blocker, in vitro on the proliferation of vascular smooth muscle cells (SMC) stimulated by foetal calf serum, basic fibroblast growth factor and platelet derived growth factor, and in vivo with regard to SMC migration and proliferation which occurred following injury of the porcine carotid artery. The intimal lesion was induced by a silasten collar surgically positioned around the carotid artery and by a stenosis reducing blood flow by 50% for 30 days. Animals received SR33805 (5 mg/kg/day) 8 days before the induction of the lesion and up to 30 days after. In vitro, SR33805 inhibited in a dose-dependent manner growth factor-induced proliferation of SMC (0.20
Keywords :
Smooth muscle cells migration , Intimal proliferation , Calcium channel antagonist , animal model , Porcine carotid artery
Journal title :
Atherosclerosis
Serial Year :
2001
Journal title :
Atherosclerosis
Record number :
630216
Link To Document :
