Crown-rump length in chromosomally abnormal fetuses at 10 to 13 weeksʹ gestation

OBJECTIVE: Our purpose was to investigate whether fetuses with aneuploidies demonstrate evidence of growth retardation during the first trimester. STUDY DESIGN: This was a retrospective, cross-sectional study of singleton pregnancies undergoing fetal karyotyping at 10 to 13 weeksʹ gestation. Measurements of crown-rump length in 135 chromosomally abnormal fetuses were compared with those in 700 chromosomally normal fetuses. RESULTS: The median crown-rump length of fetuses with trisomy 18 (n = 32) was significantly reduced. In contrast, in fetuses with trisomy 21 (n = 72), trisomy 13 (n = 11), 47,XXX (n = 6), 47,XXX (n = 6), 45,X (n = 5), and triploidy (n = 3) the crown-rump length was not lower than normal. CONCLUSION: At 10 to 13 weeksʹ gestation fetuses with trisomy 18 are growth retarded, whereas in trisomy 21, trisomy 13, and sex chromosome aneuploidy growth is normal.