Age at menarche among diethylstilbestrol granddaughters

We interviewed 542 women whose mothers were in a randomized trial of diethylstilbestrol. Effects of diethylstilbestrol on the third generation were explored by ascertaining age at menarche for the womenʹs daughters. A total of 123 daughters were ≥10 years old (52 exposed and 71 unexposed). Age at menarche was unaffected by motherʹs prenatal diethylstilbestrol exposure.