Severe vulvovaginitis associated with intravaginal nystatin therapy

A 64-year-old woman had severe vulvovaginitis develop while she was receiving intravaginal nystatin therapy for Candida glabrata infection. Mucocutaneous adverse effects have rarely been reported with nystatin despite long years of use. This complication should be included in the differential diagnosis of clinical failure of intravaginal nystatin therapy. (Am J Obstet Gynecol 2001;185:254-5.)