Title of article :
Placement of the vaginal 17β-estradiol tablets in the inner or outer one third of the vagina affects the preferential delivery of 17β-estradiol toward the uterus or periurethral areas, thereby modifying efficacy and endometrial safety
Author/Authors :
Ettore Cicinelli، نويسنده , , Edoardo Di Naro، نويسنده , , Dominique de Ziegler، نويسنده , , Maria Matteo، نويسنده , , Stella Morgese، نويسنده , , Pietro Galantino، نويسنده , , Pierre-Alain Brioschi، نويسنده , , andSergio Schonauer، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Objective: The purpose of this study was to determine the safety and efficacy of focused ultrasound surgery with magnetic resonance imaging guidance for the noninvasive treatment of uterine leiomyomas. Study Design: Fifty-five women with clinically significant uterine leiomyomas were treated. Pain and complications were assessed prospectively, and posttreatment magnetic resonance imaging was used to measure the treatment effects. Patients in three of the five centers underwent planned hysterectomy after treatment, which provided pathologic correlation of treatment. Results: Seventy-six percent of the enrolled patients completed the full treatment session. All treatments were conducted in an outpatient setting with minimal discomfort for subjects and no major complications. Pathologic examination of the uterus confirmed that magnetic resonance imaging guidance provides the safe and accurate delivery of effective levels of thermal energy with a 3-fold increase in volume of histologically documented necrosis, compared with treatment volume (6.6 ± 0.8 vs 18.4 ± 3.9 mL, P< .005). Conclusion: Magnetic resonance imaging-guided focused ultrasound surgery appears to be a well-tolerated treatment for uterine leiomyomas. (Am J Obstet Gynecol 2003;189:48-54.)
Keywords :
urethral vessel , estradiol , blood flow , Estrogen , uterine artery , Atrophy
Journal title :
American Journal of Obstetrics and Gynecology
Journal title :
American Journal of Obstetrics and Gynecology