Pregnancy outcome and prepregnancy body mass index in 2459 glucose-tolerant Danish women

tive: This study was undertaken to investigate the relationship between pregnancy outcome and prepregnancy overweight or obesity in women with a normal glucose tolerance test. Study Design: A historical cohort study of 2459 pregnant women systematically examined for gestational diabetes was performed. Information of oral glucose tolerance test results and clinical outcome were collected from medical records. Results: The risk of hypertensive complications, cesarean section, induction of labor and macrosomia was significantly increased in both overweight women (body mass index [BMI] 25.0-29.9 kg/m2) and obese women (BMI ≥ 30.0 kg/m2) compared with women who were of normal weight (BMI 18.5-24.9 kg/m2). The frequencies of shoulder dystocia, preterm delivery, and infant morbidity other than macrosomia were not significantly associated with maternal BMI. Conclusion: Prepregnancy overweight and obesity is associated with adverse pregnancy outcome in glucose-tolerant women. (Am J Obstet Gynecol 2003;189:239-44.)