Title of article :
Intravaginal metronidazole gel versus metronidazole plus nystatin ovules for bacterial vaginosis: A randomized controlled trial
Author/Authors :
Sixto Sanchez، نويسنده , , Patricia J. Garcia، نويسنده , , Katherine K. Thomas، نويسنده , , Mary Catlin، نويسنده , , King K. Holmes، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
9
From page :
1898
To page :
1906
Abstract :
Objective We compared metronidazole 0.75% gel (containing 37.5 mg metronidazole per dose) with ovules containing metronidazole 500 mg and nystatin 100,000 U, for intravaginal treatment of bacterial vaginosis (BV). Study design In a single-blinded trial, symptomatic women with BV by both Amsel and Nugent criteria were randomly assigned to gel or ovules, once nightly for 5 nights, and asked to return 3 times after treatment. Analyses were intent-to-treat. Results Of 151 women with BV by both criteria at enrollment, 138 (91%) returned at least once. Product limit estimates for persistence or recurrence of BV at 14, 42, and 104 days were 20% (95% CI 10%-29%), 38% (95% CI 25%-48%), and 52% (95% CI 37%-63%) after gel treatment, and 4% (95% CI 0%-9%), 17% (95% CI 7%-26%), and 33% (95% CI 21%-46%) after ovule treatment (P = .01). Among women without BV at first follow-up, subsequent intercourse without condoms independently predicted subsequent recurrence (P ≤ .01). Conclusion Metronidazole/nystatin ovules were significantly more effective than metronidazole gel. Unprotected sex predicted recurrence after initial improvement.
Keywords :
Bacterial vaginosisVaginitisNugent scoreAmsel criteriaMetronidazole
Journal title :
American Journal of Obstetrics and Gynecology
Serial Year :
2004
Journal title :
American Journal of Obstetrics and Gynecology
Record number :
644478
Link To Document :
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