Prostaglandin F2α increases the sensitivity of the contractile proteins to Ca2+ in human myometrium

It is not known whether agonists (other than oxytocin) increase the contractile protein sensitivity to intracellular calcium ([Ca2+]i) in human myometrium. We determined the calcium-tension relationship in the presence and absence of prostaglandin F2α (PGF2α). PGF2α increased the calcium sensitivity during both the contractile (rising) and relaxation (falling) phases of a contraction.