Title of article :
Ambulatory—not office—blood pressures decline during hormone replacement therapy in healthy postmenopausal women
Author/Authors :
Frans J van Ittersum، نويسنده , , W.Marchien van Baal، نويسنده , , Peter Kenemans، نويسنده , , Velja Mijatovic، نويسنده , , Ab JM Donker، نويسنده , , Marius J van der Mooren، نويسنده , , Coen DA Stehouwer، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
Hormone replacement therapy (HRT, estrogen plus progestagen) in postmenopausal women has beneficial effects on the cardiovascular system. However, effects on blood pressure, determined with office measurements, remain controversial. We studied the effects of HRT in 29 healthy normotensive postmenopausal women (mean age 52.3 [3.8] years, median duration of amenorrhea 34.5 months), using ambulatory blood pressure monitoring at baseline and at 3 and 12 months of follow-up. Women were randomized to two groups: an HRT group (N = 14), treated with 1 mg 17β-estradiol once daily and 5 or 10 mg dydrogesterone once daily during the third and fourth week of every 4 weeks; and a control group (C-group, N = 15), which did not receive therapy. Blood pressures did not differ between the groups at baseline (HRT group 117.1 (9.2)/74.4 (6.6) mm Hg, C-group 113.8 (11.2)/71.3 (7.4) mm Hg). During the follow-up period, changes from baseline of office blood pressures did not differ significantly between the groups. However, changes (95% CI) of mean 24-h blood pressures differed significantly between the two groups after 1 year of follow-up: a decrease of blood pressures was observed in the HRT group (Δsystolic/Δdiastolic = −5.54 [−8.86 to −2.21]/−4.23 [−6.66 to −1.80] mm Hg), whereas an increase was found in the C-group (+3.33 [−0.69 to +7.35]/+1.67 [−1.75 to +5.09] mm Hg; P [HRT v control group] = .001/.005). We conclude that HRT may have blood pressure lowering properties in healthy, normotensive postmenopausal women.
Keywords :
PostmenopausalWomen. , Hormone replacement therapy , Twenty-four-hour ambulatory bloodpressure monitoring , office blood pressures
Journal title :
American Journal of Hypertension
Journal title :
American Journal of Hypertension