Inverse relationship between potassium intake and coronary artery disease in the cholesterol-fed rabbit

We tested the hypothesis that a low level of dietary potassium intake would exacerbate the severity of vascular lesion formation in rabbit coronary arteries during high cholesterol intake. Two groups of nine rabbits were studied for 6 weeks while eating a diet containing 2% cholesterol and 0.9% sodium. The normal potassium group consumed a diet containing 1.5% potassium and the low potassium group consumed a diet containing 0.4% potassium. After 6 weeks the animals were killed, the hearts were removed, and blood samples were withdrawn from the abdominal aorta immediately before removing the heart. The hearts were sectioned and slides were prepared and fixed with hematoxylin and eosin. The numbers of normal and abnormal vessels, and those with foam cells in the subintima, were counted in selected sections. Plasma potassium concentration in the normal and low potassium intake groups averaged 4.27 ± 0.27 mmol/L and 3.90 ± 0.11 mmol/L, respectively. No differences between the groups were observed in plasma cholesterol or body weight gain. The percentages of abnormal arteries in the groups were 4.20 ± 0.35 in the normal intake group and 6.36 ± 0.50 in the low intake group, 51% greater in the normal intake group (P< .001). These results support the hypothesis that low potassium intake exacerbates the severity of subintimal lesion development in the coronary arteries.