Author/Authors :
Michael A. Province، نويسنده , , Sharon L. R. Kardia، نويسنده , , Koustubh Ranade، نويسنده , , Dabeeru C. Rao، نويسنده , , Bonnie A. Thiel، نويسنده , , Richard S. Cooper، نويسنده , , Neil Risch، نويسنده , , Stephen T. Turner، نويسنده , , David R. Cox، نويسنده , , Steven C. Hunt، نويسنده , , Alan B. Weder، نويسنده , , Eric Boerwinkle، نويسنده ,
Abstract :
Abstract
Background
Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives).
Methods
The evidence was synthesized using meta-analysis.
Results
Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage.
Conclusions
No regions show uniformly large effects on BP/hypertension in all populations.
