Title of article :
Assessment of the Genetic Component of Hypertension
Author/Authors :
Yoshiji Yamada، نويسنده , , Hitoshi Matsuo، نويسنده , , Tomonori Segawa، نويسنده , , Sachiro Watanabe، نويسنده , , Kimihiko Kato، نويسنده , , Takeshi Hibino، نويسنده , , Kiyoshi Yokoi، نويسنده , , Sahoko Ichihara، نويسنده , , Norifumi Metoki، نويسنده , , Hidemi Yoshida، نويسنده , , Kei Satoh، نويسنده , , Yoshinori Nozawa، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
8
From page :
1158
To page :
1165
Abstract :
Background Although genetic epidemiologic studies have suggested that several genetic variants increase the risk for hypertension, the genes that underlie genetic susceptibility to this condition remain to be identified definitively. We have now performed a large-scale association study to identify gene polymorphisms for reliable assessment of the genetic component of hypertension. Methods The study population comprised 4853 unrelated Japanese individuals, including 2818 subjects with hypertension (1677 men, 1141 women) and 2035 controls (1011 men, 1024 women). The genotypes for 150 polymorphisms of 128 candidate genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Results Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of smoking revealed that four polymorphisms (1648G→A in ITGA2, −30G→A in GCK, A→G in SAH, and 1117C→A in PTGIS) were significantly (P< .01) associated with hypertension. A stepwise forward selection procedure demonstrated that ITGA2, GCK, and PTGIS genotypes significantly affected the prevalence of hypertension. Combined genotype analysis of these polymorphisms yielded a lowest odds ratio of 0.47 for the genotypes of AA or AG for ITGA2, GA or AA for GCK, and CC for PTGIS, which were present in 1.1% and 2.0% of hypertensive and control individuals, respectively. Conclusions These results suggest that the genotypes for ITGA2, GCK, and PTGIS may prove reliable for the assessment of the genetic component of hypertension. Determination of the combined genotypes for these genes may contribute to personalized prevention of this condition.
Keywords :
hypertension , blood pressure , genetics , genetic polymorphism , Risk factors.
Journal title :
American Journal of Hypertension
Serial Year :
2006
Journal title :
American Journal of Hypertension
Record number :
649549
Link To Document :
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