Increased Circulating CD31+/CD42− Microparticles Are Associated With Impaired Systemic Artery Elasticity in Healthy Subjects

Background Impaired artery elasticity has been found in various pathological conditions related to endothelial dysfunction. Recently, CD31+/CD42− microparticles (MPs) emerged as a marker of endothelial injury. Whether CD31+/CD42− MPs, generated under physiological conditions, are correlated with artery properties has not been reported. Methods We evaluated brachia–ankle pulse-wave velocity (baPWV) (n = 76) and C1 large-artery and C2 small-artery elasticity indices (n = 56), using noninvasive devices for pulse-wave analysis in a group of healthy persons. The number of circulating CD31+/CD427− MPs (n = 76) was measured by flow cytometric analysis. Results Circulating CD31+/CD42− MPs were positively correlated with values of baPWV (r = 0.371, P = .008) and with C1 large-artery and C2 small-artery elasticity indices (r = −0.294, P = .037; and r = −0.310, P = .027, respectively). Multivariate analysis identified CD31+/CD42− MPs as potent contributors to the development of impaired systemic artery elasticity. Conclusions The level of circulating CD31+/CD42− MPs, an important biomarker of dysfunctional endothelium and vascular injury, is closely associated with impaired systemic artery elasticity in healthy subjects. The present study suggests that CD31+/CD42− MPs may be a novel surrogate marker for the clinical evaluation of vascular damage.