Hormonal pattern in hypertensives with and without renal insufficiency

To study the behaviour and the relationship both of some hormones and atrial natriuretic factor (ANF) in hypertensive patients with renal insufficiency (CRFs) and in essential hypertensives (EHs) with normal renal function. In 25 moderate hypertensive CRFs (serum creatinine 4.4±0.5 mg%, creatinine clearance 25±4.2 ml/min) and in 15 moderate EHs (Cs 0.9±0.1 mg%, Ccr 126±10 ml/min), after an overnight fasting and resting, and after 2hs of standing, were evaluated: plasma aldosterone (PAC), ANF, epinephrine (E) norepinephrine (NE) and levels, and PRA. In hypertensive CRFs significantly higher PAC values than in EHs, both at rest and after standing, were observed (290.4±52 vs 91.6±9, and 594±88.4 vs 192.2±24.2 pg/ml, p<0.005 respectively). Not different mean values of ANF, PRA,NE and E, both at rest and after standing were obtained. In CRFs group, resting PAC positively correlated to serum creatinine (Cs) (r 0.42,p<0.05) and negatively to creatinine clearance (Ccr) (r − 0.57, p<0.01). On the contrary, in EHs, PAC was inversely correlated with Cs (r − 0.80, p<0.001) and positively with Ccr (r 0.55, p<0.05). Moreover, in EHs significant correlations of basal ANF with both Cs and Ccr (r 0.70, p<0.01; r − 0.55, p<0.05 respectively), and of ANF with PAC after standing, were found. Our results show that hypertensive CRFs are characterized by higher PAC levels than EHs, which are not related to both ANF and PRA, while significantly correlate to renal function parameters.