Author/Authors :
Yu، Jeong J. نويسنده , , Kwak، Byung O. نويسنده , , Jeon، You H. نويسنده ,
Abstract :
Our aim was to determine whether the index of left ventricular mass increases during the acute and
subacute phase of Kawasaki disease, and to investigate any relationship between this index and clinical and
echocardiographic variables. We performed, therefore, a retrospective study of 66 children with Kawasaki
disease, having a mean age of 2.85 years, comparing the findings with those obtained from 57 normal controls,
having a mean age of 2.99 years. The data from the patients used for comparison was obtained during the acute
and subacute phase of the illness, as well as during the phase of convalescence.We performed correlation analysis
of the findings during the acute and subacute phase, determining the relationship between the index of left
ventricular mass and other variables. The index was higher (p50.0461), and the velocity of propagation of left
ventricular early diastolic flow was lower (p,0.0001), during the acute and subacute phase when compared to
control values. The index then reduced (p50.0001) during the phase of convalescent when compared to the
acute and subacute phase. Levels of albumin in the serum (p50.0193), peak E velocity (p50.0479), and
velocity of propagation (p50.0360) were found to be related to the index of left ventricular mass. Significant
relationships were found between the differences in this index and differences in body weight when findings
during the acute and subacute phase were compared to those of the phase of convalescence. The index of left
ventricular mass, therefore, is increased during the acute and subacute phase of Kawasaki disease, and is
associated with altered diastolic indexes. This elevation may be due to generalized myocardial swelling from
acute inflammation and increased vascular permeability. Measuring this index as a potential predictor of diastolic
function should be added to studies of cardiac function during the acute and subacute phase of Kawasaki disease.