Author/Authors :
Bozorgmanesh، A.R نويسنده Department of Mathematics, Science and Research Branch, Islamic Azad University, Tehran, Iran , , Otadi، M نويسنده Department of Chemical Engineering,Central Branch, Islamic Azad University, Tehran, Iran , , Safe Kordi، A.A نويسنده Department of Chemical Engineering,Sharif University of Technology, Tehran, Iran , , Zabihi، F نويسنده Department of Chemical Engineering, Ayatollah Amoli Branch, Islamic Azad University,Amol, Iran , , Barkhordari Ahmadi، M نويسنده Department of Mathematics,Bandar Abbas Branch, Islamic Azad University,Bandar Abbas, Iran ,
Abstract :
In the pharmaceutical industry, a great number of products are in the form of particulate
solids. Since the mid-1980s, a new method of powder generation has appeared involving
crystallisation with supercritical
uids (SCF). The rapid expansion of supercritical solutions
(RESS) is a promising new process for the production of small and uniform particles.
Several variables can in
uence the RESS process: the nozzle temperature, preexpansion
pressure, the nozzle diameter, and geometry. In this work, a two-dimensional Lagrange interpolation
method has been proposed to describe the size of nanoparticle forming through
the rapid expansion of supercritical solutions, as a function of preexpansion pressure and
nozzle temperature.
