Author/Authors :
Sefidbakht، Sepideh نويسنده Department of Radiology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Ashouri-Taziani، Yaghoub نويسنده Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Hoseini، Sareh نويسنده Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Ansrai، Mansour نويسنده Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , AHMADLOO، NILOOFAR نويسنده , , MOSALAEI، AHMAD نويسنده , , OMIDVARI، SHAPOUR نويسنده , , Nasrolahi، Hamid نويسنده Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , MOHAMMADIANPANAH، MOHAMMAD نويسنده ,
Abstract :
Osteopoikilosis is a rare benign osteosclerotic bone disorder that may be misdiagnosed
as skeletal metastases. Here we describe a case of coincidental breast cancer and
osteopoikilosis mimicking skeletal metastases. A 41-year-old woman underwent right
modified radical mastectomy in April 2007. Twenty-eight months after initial treatment,
the patient complained of bilateral knee and foot pain. Plain X-rays of the feet and knees
showed multiple well-defined osteosclerotic lesions. According to the radiographic
appearance, the most likely differential diagnoses included skeletal metastases from
breast cancer and osteopoikilosis. A whole-body bone scintigraphy showed no increase
in uptake by the sclerotic lesions, and serum lactic dehydrogenase, carcinoembryon-
ic antigen, alkaline phosphatase and cancer antigen 15-3 were not elevated. We
therefore diagnosed the patient’s skeletal lesions as osteopoikilosis. This case and our
literature review suggest that the radiographic appearance of osteopoikilosis may
mimic or mask skeletal metastases, potentially leading to misdiagnosis in patients with
cancer.
