Synthesis of Some New Thiazolidinones Derived from 1-p-Tolylethanone and Their Antibacterial and Antifungal Activities

Some new 3-(substitutedphenyl)-2-methyl-2-p-tolylthiazolidin-4-ones (3a-t) were prepared by refluxing the 1-p-tolylethanone (1) with different aromatic amines (2a-t) in presence of thioglycolic acid in benzene (one pot synthesis). The title compounds have been characterized on the basis of elemental analysis, IR, 1H-NMR and 13C-NMR spectral data. All the synthesized compounds have been screened against four different bacterial strains S. aureus, S. paratyphi-A, E. coli and B. subtilis and fungal strain F. molaniforme and A. niger. Some of them showed good antibacterial and antifungal activity compared to reference drugs used in the study.