Author/Authors :
Khademi، Bijan نويسنده , , Bahranifard، Hajar نويسنده Cancer Research Center and Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran , , kabiri، seyed Hamed نويسنده Department of Surgery, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , razzaghi، samiraz نويسنده Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Hashemi، Seyed Basir نويسنده Department of Otolaryngology, Head and Neck Surgery, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , shishegar، mahmoud نويسنده Department of Otolaryngology, Head and Neck Surgery, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , MOHAMMADIANPANAH، MOHAMMAD نويسنده ,
Abstract :
Background: The present study aimed to report the characteristics and treatment
outcomes of five patients with nasopharyngeal adenoid cystic carcinoma and a literature
review.
Methods: Between 2000 and 2009, five consecutive patients (4 men, 1 woman) were
diagnosed with nasopharyngeal adenoid cystic carcinoma and treated at our institution.
Three patients had stage IVa (T4N0M0) and two patients had stage III (T3N0M0) cancer.
Primary treatment consisted of concurrent chemoradiation in three patients and
radiotherapy alone in two patients. Surgery was limited to endoscopic biopsy for
histological diagnosis.
Results: Four patients achieved complete response during or after completion of
treatment and remained free of disease for a median of 27 months. Four patients
developed local recurrence 8-30 months after initial treatment. The fifth patient is alive
and free of disease.
Conclusion: The findings of the present study and literature review suggest that
local failure is a major problem in adenoid cystic carcinoma of the nasopharynx.
