Increased Circulating Angiotensin II as a Prognostic Factor in Acute Coronary Syndrome

Background- Angiotensin II promotes atherogenesis and modulates plaque vulnerability mainly by stimulating inflammatory mechanisms. The aim of this study was to investigate changes in the plasma level of angiotensin II in acute coronary syndrome. Methods- The plasma level of angiotensin II was measured using the radioimmunoassay method in 81 patients with acute coronary syndrome, consisting of 34 patients with unstable angina and 47 patients with acute MI, and in 80 non-ischemic patients (control group). Results- The plasma level of angiotensin II was significantly higher in the acute MI patients than that in the control group (11.3پ}7.50 pg/ml versus 9.72پ}8.30 pg/ml, P value<0.05) (Iranian Heart Journal 2005; 6 (3): 39-41).