Comparative Study of Ligand Docking

Anti-apoptotic proteins play an vital role in deactivating the apoptosis process in cancer disease. Apoptosis process can be activated in cancer state by inhibiting anti-apoptotic proteins. Apoptosis occurs via 2 main signalling pathways the Intrinsic and Extrinsic pathways. Extrinsic pathway is regulated by p53 protein, cyt c and apaf-1 regulates the intrinsic pathway. A class of caspase cascades (2,3,6,7,8,9) helps in induction, transduction, amplification and execution of apoptotic signals in intrinsic and extrinsic signalling pathways. Comparative docking studies are done on the anti-apototic proteins which disclosed their interaction energies. Hence forth anti-apoptotic proteins were chosen to perform docking studies which are assumed that the inhibitors/chemical ligands can activate apoptosis process which may precede to inhibit cancer cells uncontrolled proliferation.